Please use this identifier to cite or link to this item:
http://dspace.mediu.edu.my:8181/xmlui/handle/10261/1433| Title: | NMDA treatment stabilizes the mRNA encoding for α2 subunit of the NO-sensitive guanylyl cyclase by decreasing AUF1 protein level through a NO-cGMP-dependent mechanism |
| Publisher: | BioMed Central |
| Description: | From 2nd International Conference of cGMP Generators, Effectors and Therapeutic Implications
Potsdam, Germany, 10–12 June, 2005 First paragraph (this article has no abstract) Posttranscriptional mechanisms of gene regulation, particularly those affecting mRNA stability, are emerging as critical effectors of gene expression changes. Although the mechanisms determining mRNA turnover are poorly understood, they are generally believed to involve RNA-binding proteins recognizing specific RNA sequences. Best characterized among the RNA sequences that influence mRNA stability are AU-rich elements (AREs), usually found in the 3'untraslated regions (UTR). The stability of a particular mRNA is controlled by specific interactions between structural elements of the mRNA and RNA-binding proteins. Of these proteins the best studied are AUF1 proteins that destabilize and ELAV-like proteins that stabilizes different mRNAs. Peer reviewed |
| URI: | http://dspace.mediu.edu.my:8181/xmlui/handle/10261/1433 |
| Other Identifiers: | BMC Pharmacology 2005, 5(Suppl 1):P55 1471-2210 http://hdl.handle.net/10261/1433 10.1186/1471-2210-5-S1-P55 |
| Appears in Collections: | Digital Csic |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.