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http://dspace.mediu.edu.my:8181/xmlui/handle/10261/1444| Title: | SPOC: A widely distributed domain associated with cancer, apoptosis and transcription |
| Publisher: | BioMed Central |
| Description: | This article is available from: http://www.biomedcentral.com/1471-2105/5/91 [Background] The Split ends (Spen) family are large proteins characterised by N-terminal RNA recognition motifs (RRMs) and a conserved SPOC (Spen paralog and ortholog C-terminal) domain. The aim of this study is to characterize the family at the sequence level. [Results] We describe undetected members of the Spen family in other lineages (Plasmodium and Plants) and localise SPOC in a new domain context, in a family that is common to all eukaryotes using profile-based sequence searches and structural prediction methods. [Conclusions] The widely distributed DIO (Death inducer-obliterator) family is related to cancer and apoptosis and offers new clues about SPOC domain functionality. This study was financed in part by the VITH EU Framework Project QLGI-CT-2001-01536. Peer reviewed |
| URI: | http://dspace.mediu.edu.my:8181/xmlui/handle/10261/1444 |
| Other Identifiers: | BMC Bioinformatics 2004, 5:91 1471-2105 http://hdl.handle.net/10261/1444 10.1186/1471-2105-5-91 |
| Appears in Collections: | Digital Csic |
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