Please use this identifier to cite or link to this item:
http://dspace.mediu.edu.my:8181/xmlui/handle/10261/2724Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.creator | González de la Peña, Manuel Angel | - |
| dc.creator | Serrano Gómez, Fernando | - |
| dc.creator | Abad, José Luis | - |
| dc.creator | Bernad, Antonio | - |
| dc.creator | Llorente Gómez, María de las Mercedes | - |
| dc.creator | Martínez-Alonso, Carlos | - |
| dc.creator | Garmendia Mendizábal, Cristina | - |
| dc.date | 2008-01-22T08:11:12Z | - |
| dc.date | 2008-01-22T08:11:12Z | - |
| dc.date | 2004-12-02 | - |
| dc.date.accessioned | 2017-01-31T00:59:45Z | - |
| dc.date.available | 2017-01-31T00:59:45Z | - |
| dc.identifier | International Publication Number: WO 2004/013330 A1 | - |
| dc.identifier | http://hdl.handle.net/10261/2724 | - |
| dc.identifier.uri | http://dspace.mediu.edu.my:8181/xmlui/handle/10261/2724 | - |
| dc.description | Filing Date: 2003-07-10.--Priority Data: ES P200201776 (2002-07-26) | - |
| dc.description | The invention relates to multifunctional genetic constructions which can mimic the HIV-1-resistant phenotype in individuals with mutations that functionally inactivate the CCR5 chemokine receptor. In this way, the invention relates to various therapeutic genetic constructions which can inhibit specifically the expression of the aforementioned receptor in human cells and to retroviral vectors which can be used to introduce therapeutic genes into said cells. Moreover, the invention relates to a genetic transduction system based on the above-mentioned vectors with applications in experimental animal models and clinical treatments for HIV-1. The functional inactivation systems outlined herein can also be used to research and treat other human pathologies involving the CCR5 protein or other chemokine receptors. | - |
| dc.format | 3780143 bytes | - |
| dc.format | application/pdf | - |
| dc.language | spa | - |
| dc.rights | openAccess | - |
| dc.title | Multifunctional genetic constructions having a high capacity to inhibit the expression of CCR5 on the cell surface | - |
| dc.title | Construcciones genéticas multifuncionales con alta capacidad inhibitoria de la expresión de CCR5 en la superficie celular | - |
| dc.type | Patente | - |
| Appears in Collections: | Digital Csic | |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.