Please use this identifier to cite or link to this item:
http://dspace.mediu.edu.my:8181/xmlui/handle/10261/3075| Title: | Convergence of the TOR and the Snf1 protein kinase pathways in the regulation of the subcellular localization of Msn2, a transcriptional activator of STRE regulated genes |
| Keywords: | protein kinase pathways Stress regulated genes |
| Publisher: | American Society for Biochemistry and Molecular Biology |
| Description: | The subcellular localization of Msn2, a transcriptional activator of STRE (Stress Response Element) regulated genes, is modulated by carbon source availability. In cells growing in glucose, Msn2 is located mainly in the cytosol, whereas in carbon source-starved cells, Msn2 is located largely inside the nucleus. However, in cells lacking Reg1 (the regulatory subunit of the Reg1/Glc7 protein phosphatase complex), the regulation of subcellular distribution is absent, Msn2 being constitutively present in the cytosol. The localization defect in these mutants is specific for carbon starvation stress and it is due to the presence of an abnormally active Snf1 protein kinase that inhibits the nuclear localization of Msn2 upon carbon starvation. Active Snf1 kinase is also able to avoid the effects of rapamycin, a drug that by inhibiting the TOR kinase pathway leads to a nuclear localization of Msn2 in wild type cells. Therefore, active Snf1 and the TOR kinase pathway may affect similar cytosolic steps in the regulation of the subcellular localization of Msn2. Spanish Ministry of Education and Science Grant PB98-0486. |
| URI: | http://dspace.mediu.edu.my:8181/xmlui/handle/10261/3075 |
| Other Identifiers: | Journal of Biological Chemistry 277(38) : 35650-35656 (2002) http://hdl.handle.net/10261/3075 |
| Appears in Collections: | Digital Csic |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.