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http://dspace.mediu.edu.my:8181/xmlui/handle/10261/3352| Title: | Securin Is a Target of the UV Response Pathway in Mammalian Cells |
| Authors: | Ministerio de Ciencia y Tecnología (España) Junta de Andalucía Instituto de Salud Carlos III (España) Asociación de Padres de Niños con Cáncer de Andalucía |
| Publisher: | American Society for Microbiology |
| Description: | All eukaryotic cells possess elaborate mechanisms to protect genome integrity and ensure survival after DNA
damage, ceasing proliferation and granting time for DNA repair. Securin is an inhibitory protein that is bound
to a protease called Separase to inhibit sister chromatid separation until the onset of anaphase. At the
metaphase-to-anaphase transition, Securin is degraded by the anaphase-promoting complex or cyclosome, and
Separase contributes to the release of cohesins from the chromosome, allowing for the segregation of sister
chromatids to opposite spindle poles. Here we provide evidence that human Securin (hSecurin) has a novel role
in cell cycle arrest after exposure to UV light or ionizing radiation. In fact, irradiation downregulated the level
of hSecurin protein, accelerating its degradation via the proteasome and reducing hSecurin mRNA translation,
but the presence of hSecurin is necessary for cell proliferation arrest following UV treatment. Moreover, an
alteration of UV-induced hSecurin downregulation could lead directly to the accumulation of DNA damage and
the subsequent development of malignant tumors. This work was supported by grants from Ministerio de Ciencia y Tecnología of Spain (SAF2002-04177-C04), DGUI of the Junta de Andalucía, and Fundación ANDEX. F.R. and C.S. were supported by Ramón y Cajal and Instituto de la Salud Carlos III contracts, respectively. Peer reviewed |
| URI: | http://dspace.mediu.edu.my:8181/xmlui/handle/10261/3352 |
| Other Identifiers: | Molecular and Cellular Biology 24(7): 2720–2733 (2004) 1098-5549 http://hdl.handle.net/10261/3352 10.1128/MCB.24.7.2720-2733.2004 |
| Appears in Collections: | Digital Csic |
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