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Please use this identifier to cite or link to this item: http://dspace.mediu.edu.my:8181/xmlui/handle/10261/3387
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dc.creatorLacalle, Rosa Ana-
dc.creatorMira, Emilia-
dc.creatorGómez-Moutón, Concepción-
dc.creatorJiménez Baranda, Sonia-
dc.creatorMartínez-Alonso, Carlos-
dc.creatorMañes, Santos-
dc.date2008-03-31T10:27:04Z-
dc.date2008-03-31T10:27:04Z-
dc.date2002-04-
dc.date.accessioned2017-01-31T01:01:22Z-
dc.date.available2017-01-31T01:01:22Z-
dc.identifierThe Journal of Cell Biology, volume 157, number 2, april 15, 2002, pp. 277–289-
dc.identifier0021-9525-
dc.identifierhttp://hdl.handle.net/10261/3387-
dc.identifier10.1083/jcb.200109031-
dc.identifier.urihttp://dspace.mediu.edu.my:8181/xmlui/handle/10261/3387-
dc.descriptionCopyright © by The Rockefeller University Press-
dc.descriptionCell signaling does not occur randomly over the cell surface, but is integrated within cholesterol-enriched membrane domains, termed rafts. By targeting SHP-2 to raft domains or to a non-raft plasma membrane fraction, we studied the functional role of rafts in signaling. Serumdepleted, nonattached cells expressing the raft SHP-2 form, but not non-raft SHP-2, display signaling events resembling those observed after fibronectin attachment, such as 1 integrin clustering, 397 Y-FAK phosphorylation, and ERK activation, and also increases Rho-GTP levels. Expression of C the dominant negative N19Rho abrogates raft-SHP-2–induced signaling, suggesting that Rho activation is a downstream event in SHP-2 signaling. Expression of a catalytic inactive SHP-2 mutant abrogates the adhesion-induced feedback inhibition of Rho activity, suggesting that SHP-2 contributes to adhesion-induced suppression of Rho activity. Because raft recruitment of SHP-2 occurs physiologically after cell attachment, these results provide a mechanism by which SHP-2 may influence cell adhesion and migration by spatially regulating Rho activity.-
dc.descriptionPeer reviewed-
dc.format696619 bytes-
dc.formatapplication/pdf-
dc.languageeng-
dc.publisherRockefeller University Press-
dc.rightsopenAccess-
dc.titleSpecific SHP-2 partitioning in raft domains triggers integrin-mediated signaling via Rho activation-
dc.typeArtículo-
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