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http://dspace.mediu.edu.my:8181/xmlui/handle/10261/3467Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.creator | Cerezo, Ana | - |
| dc.creator | Martínez-Alonso, Carlos | - |
| dc.creator | Lanzarot, Diego | - |
| dc.creator | Fischer, Siegmund | - |
| dc.creator | Franke, Thomas F. | - |
| dc.creator | Rebollo, Angelita | - |
| dc.date | 2008-04-08T09:50:19Z | - |
| dc.date | 2008-04-08T09:50:19Z | - |
| dc.date | 1998-11 | - |
| dc.date.accessioned | 2017-01-31T01:01:37Z | - |
| dc.date.available | 2017-01-31T01:01:37Z | - |
| dc.identifier | Molecular Biology of the Cell, Vol. 8, pp. 3107–3118, November 1998 | - |
| dc.identifier | 1059-1524 | - |
| dc.identifier | http://hdl.handle.net/10261/3467 | - |
| dc.identifier.uri | http://dspace.mediu.edu.my:8181/xmlui/handle/10261/3467 | - |
| dc.description | El copyright pertenece a The American Society for Cell Biology. The final versión of the paper is available at http://www.pubmedcentral.nih.gov | - |
| dc.description | We have shown previously that interleukin-4 (IL-4) protects TS1ab cells from apoptosis, but very little is known about the mechanism by which IL-4 exerts this effect. We found that Akt activity, which is dependent on phosphatidylinositol 3 kinase, is reduced in IL-4-deprived TS1ab cells. Overexpression of wild-type Akt or a constitutively active Akt mutant protects cells from IL-4 deprivation-induced apoptosis. Readdition of IL-4 before the commitment point is able to restore Akt activity. We also show expression and c-Jun N-terminal kinase 2 activation after IL-4 deprivation. Overexpression of the constitutively activated Akt mutant in IL-4-deprived cells correlates with inhibition of c-Jun N-terminal kinase 2 activity. Finally, TS1ab survival is independent of Bcl-2, Bcl-x, or Bax. | - |
| dc.description | Peer reviewed | - |
| dc.format | 360048 bytes | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | American Society for Cell Biology | - |
| dc.rights | openAccess | - |
| dc.title | Role of Akt and c-Jun N-terminal Kinase 2 in Apoptosis Induced by Interleukin-4 Deprivation | - |
| dc.type | Artículo | - |
| Appears in Collections: | Digital Csic | |
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