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http://dspace.mediu.edu.my:8181/xmlui/handle/10261/3613Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.creator | Stein, Jens V. | - |
| dc.creator | López Fraga, Marta | - |
| dc.creator | Elustondo, Fernando A. | - |
| dc.creator | Carvalho-Pinto, Carla E. | - |
| dc.creator | Rodríguez Aguirre, Dolores | - |
| dc.creator | Gómez Caro, Ruth | - |
| dc.creator | Jong, Joan de | - |
| dc.creator | Martínez-Alonso, Carlos | - |
| dc.creator | Medema, Jan Paul | - |
| dc.creator | Hahne, Michael | - |
| dc.date | 2008-04-16T09:36:37Z | - |
| dc.date | 2008-04-16T09:36:37Z | - |
| dc.date | 2002-06 | - |
| dc.date.accessioned | 2017-01-31T01:02:26Z | - |
| dc.date.available | 2017-01-31T01:02:26Z | - |
| dc.identifier | The Journal of Clinical Investigation, vol. 109(12), pp. 1587-1598, (2002) | - |
| dc.identifier | 0021-9738 | - |
| dc.identifier | http://hdl.handle.net/10261/3613 | - |
| dc.identifier | 10.1172/JCI15034 | - |
| dc.identifier.uri | http://dspace.mediu.edu.my:8181/xmlui/handle/10261/3613 | - |
| dc.description | The final version of this paper is available at: http://dx.doi.org/10.1172/JCI15034 | - |
| dc.description | The TNF-like ligands APRIL and BLyS are close relatives and share the capacity to bind the receptors TACI and BCMA. BLyS has been shown to play an important role in B cell homeostasis and autoimmunity, but the biological role of APRIL remains less well defined. Analysis of T cells revealed an activation-dependent increase in APRIL mRNA expression. We therefore generated mice expressing APRIL as a transgene in T cells. These mice appeared normal and showed no signs of B cell hyperplasia. Transgenic T cells revealed a greatly enhanced survival in vitro as well as enhanced survival of staphylococcal enterotoxin B-reactive CD4+ T cells in vivo, which both directly correlate with elevated Bcl-2 levels. Analysis of humoral responses to T cell-dependent antigens in the transgenic mice indicated that APRIL affects only IgM but not IgG responses. In contrast, T cell-independent type 2 (TI-2) humoral response was enhanced in APRIL transgenic mice. As TACI was previously reported to be indispensable for TI-2 antibody formation, these results suggest a role for APRIL/TACI interactions in the generation of this response. Taken together, our data indicate that APRIL is involved in the induction and/or maintenance of T and B cell responses. | - |
| dc.description | Peer reviewed | - |
| dc.format | 990129 bytes | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | American Society for Clinical Investigation | - |
| dc.rights | openAccess | - |
| dc.title | APRIL modulates B and T cell immunity | - |
| dc.type | Artículo | - |
| Appears in Collections: | Digital Csic | |
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