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http://dspace.mediu.edu.my:8181/xmlui/handle/10261/3613| Title: | APRIL modulates B and T cell immunity |
| Publisher: | American Society for Clinical Investigation |
| Description: | The final version of this paper is available at: http://dx.doi.org/10.1172/JCI15034 The TNF-like ligands APRIL and BLyS are close relatives and share the capacity to bind the receptors TACI and BCMA. BLyS has been shown to play an important role in B cell homeostasis and autoimmunity, but the biological role of APRIL remains less well defined. Analysis of T cells revealed an activation-dependent increase in APRIL mRNA expression. We therefore generated mice expressing APRIL as a transgene in T cells. These mice appeared normal and showed no signs of B cell hyperplasia. Transgenic T cells revealed a greatly enhanced survival in vitro as well as enhanced survival of staphylococcal enterotoxin B-reactive CD4+ T cells in vivo, which both directly correlate with elevated Bcl-2 levels. Analysis of humoral responses to T cell-dependent antigens in the transgenic mice indicated that APRIL affects only IgM but not IgG responses. In contrast, T cell-independent type 2 (TI-2) humoral response was enhanced in APRIL transgenic mice. As TACI was previously reported to be indispensable for TI-2 antibody formation, these results suggest a role for APRIL/TACI interactions in the generation of this response. Taken together, our data indicate that APRIL is involved in the induction and/or maintenance of T and B cell responses. Peer reviewed |
| URI: | http://dspace.mediu.edu.my:8181/xmlui/handle/10261/3613 |
| Other Identifiers: | The Journal of Clinical Investigation, vol. 109(12), pp. 1587-1598, (2002) 0021-9738 http://hdl.handle.net/10261/3613 10.1172/JCI15034 |
| Appears in Collections: | Digital Csic |
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