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| DC Field | Value | Language |
|---|---|---|
| dc.creator | Hera, Antonio de la | - |
| dc.creator | Marcos, Miguel A. R. | - |
| dc.creator | Toribio, María Luisa | - |
| dc.creator | Márquez, Carlos | - |
| dc.creator | Gaspar, Maria Luisa | - |
| dc.creator | Martínez-Alonso, Carlos | - |
| dc.date | 2008-04-22T12:11:56Z | - |
| dc.date | 2008-04-22T12:11:56Z | - |
| dc.date | 1987-09 | - |
| dc.date.accessioned | 2017-01-31T01:03:03Z | - |
| dc.date.available | 2017-01-31T01:03:03Z | - |
| dc.identifier | The Journal of Experimental Medicine, Vol. 166, Septembre (1987), pp. 804-809 | - |
| dc.identifier | 0022-1007 | - |
| dc.identifier | http://hdl.handle.net/10261/3678 | - |
| dc.identifier.uri | http://dspace.mediu.edu.my:8181/xmlui/handle/10261/3678 | - |
| dc.description | El copyright pertenece a The Rockefeller University Press | - |
| dc.description | Developmental analyses of B cell differentiation are consistent with the existence of at least two distinct lineages . Thus, adult bone marrow solely regenerates the commonest (Ly-1 -) lineage, while Ly-1 + B cells reconstitute the Ly-1 + B cell lineage (1). CBA/N mice carrying the X-linked immunodeficiency gene (xid) show a defective differentiation of B lymphocytes (2) . They lack all Ly-1 + B cells as well as the normally predominant subpopulation within the Ly-1 - lineage (3) . Functional studies (4) indicated that Ly-1 + B cells are responsible for the production of most of the autoantibodies, while those B cells in the Ly-1 - lineage participate in the conventional responses to "foreign" antigens. These observations may account for both the protection conferred against autoimmune disease, when the xid genetic defect is bred into lupus-prone strains, and the CBA/N mice unresponsiveness to many bacterial antigens (5, 6) . Administration of the immunosuppressant cyclosporine A (CsA) at the time of autologous bone marrow reconstitution results in systemic autoimmunity in CBA/N mice. Besides, these mice show a severe diminution, if not absence, of bone marrow pre-B cells, but increased amounts of activated B cells and autoantibodies (7). We have now studied the possibility that Ly-1 + B cell precursors may exist in CBA/N mice and report here experiments indicating that this is indeed the case | - |
| dc.description | Peer reviewed | - |
| dc.format | 392959 bytes | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | Rockefeller University Press | - |
| dc.rights | openAccess | - |
| dc.title | Development of Ly-1+ B Cells in immunodeficient CBA/N mice | - |
| dc.type | Artículo | - |
| Appears in Collections: | Digital Csic | |
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