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| DC Field | Value | Language |
|---|---|---|
| dc.creator | Andreu-Sánchez, Jose L. | - |
| dc.creator | Moreno de Alborán, Ignacio | - |
| dc.creator | Marcos, Miguel A. R. | - |
| dc.creator | Sánchez-Movilla, Arsenio | - |
| dc.creator | Martínez-Alonso, Carlos | - |
| dc.creator | Kroemer, Guido | - |
| dc.date | 2008-04-23T11:07:40Z | - |
| dc.date | 2008-04-23T11:07:40Z | - |
| dc.date | 1991-06 | - |
| dc.date.accessioned | 2017-01-31T01:03:12Z | - |
| dc.date.available | 2017-01-31T01:03:12Z | - |
| dc.identifier | The Journal of Experimental Medicine, Volume 173, June 1991, pp. 1323-1329 | - |
| dc.identifier | 0022-1007 | - |
| dc.identifier | http://hdl.handle.net/10261/3694 | - |
| dc.identifier.uri | http://dspace.mediu.edu.my:8181/xmlui/handle/10261/3694 | - |
| dc.description | El copyright pertenece a The Rockefeller University Press | - |
| dc.description | Under physiological conditions, the vast majority of T cells differentiate in the thymus, an organ that provides an optimal microenvironment for T cell maturation and shapes the T cell repertoire via positive and negative selection processes. In the present report, we demonstrate that neonatal thymectomy of CBA/H mice results in a diminution of T cells in peripheral lymphoid organs (spleen, lymph nodes), but is followed by a marked transient (12 wk) increase in Thy-1+ CD3+ cells in the peritoneal cavity. These cells exhibit predominantly a double-negative (CD4 - CD8 - ) phenotype among which products of the T cell receptor (TCR) VO11 gene family (i.e., an I-Ereactive TCR normally deleted in I-E-bearing CBA/H mice) are selectively overexpressed . This observation suggests that, under athymic conditions, T cell differentiation and/or accumulation may occur in the peritoneal cavity. Intraperitoneal inoculation of an interleukin 2 (IL2) vaccinia virus construct that releases high titers of human IIr2 in vivo induces conversion of these doublenegative T cells to either CD4+CD8 - or CD4-CD8+ single positives, and allows in vitro stimulation of TCR V,311-bearing cells with a clonotypic antiVO antibody. Since IL-2 induces autoimmune manifestations (DNA autoantibodies, rheumatoid factors, and interstitial nephritis) in thymectomized CBA/H mice, but not in sham-treated littermates, this lymphokine is likely to enhance the autoaggressive function of T cells that bear forbidden, potentially autoreactive TCR gene products and that are normally deleted in the thymus. | - |
| dc.description | Peer reviewed | - |
| dc.format | 977218 bytes | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | Rockefeller University Press | - |
| dc.rights | openAccess | - |
| dc.title | Interleukin 2 abrogates the nonresponsive state of T cells expressing a forbidden T cell receptor repertoire and induces autoimmune disease in neonatally thymectomized mice | - |
| dc.type | Artículo | - |
| Appears in Collections: | Digital Csic | |
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