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http://dspace.mediu.edu.my:8181/xmlui/handle/10261/4094Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.creator | Aguilera, Andrés | - |
| dc.creator | Gómez-González, Belén | - |
| dc.date | 2008-05-08T15:17:30Z | - |
| dc.date | 2008-05-08T15:17:30Z | - |
| dc.date | 2008-03 | - |
| dc.date.accessioned | 2017-01-31T01:12:32Z | - |
| dc.date.available | 2017-01-31T01:12:32Z | - |
| dc.identifier | Nature Reviews Genetics 9: 204-217 (2008) | - |
| dc.identifier | 1471-0056 | - |
| dc.identifier | http://hdl.handle.net/10261/4094 | - |
| dc.identifier | 10.1038/nrg2268 | - |
| dc.identifier.uri | http://dspace.mediu.edu.my:8181/xmlui/handle/10261/4094 | - |
| dc.description | 14 páginas, 6 figuras, 1 tabla. PMID: 18227811.-- Final full-text version of the paper available at: http://dx.doi.org/10.1038/nrg2268.-- Supplementary material available at: http://www.nature.com/nrg/journal/v9/n3/extref/nrg2268-s1.pdf | - |
| dc.description | Genomic instability in the form of mutations and chromosome rearrangements is usually associated with pathological disorders, and yet it is also crucial for evolution. Two types of elements have a key role in instability leading to rearrangements: those that act in trans to prevent instability -among them are replication, repair and S-phase checkpoint factors- and those that act in cis -chromosomal hotspots of instability such as fragile sites and highly transcribed DNA sequences. Taking these elements as a guide, we review the causes and consequences of instability with the aim of providing a mechanistic perspective on the origin of genomic instability. | - |
| dc.description | Research in A.A.’s laboratory is funded by grants from the Spanish Ministry of Science and Education (BFU2006‑05260), Consolider Ingenio 2010 (CDS2007‑015) and Junta de Andalucía (CVI102 and CVI624). | - |
| dc.description | Peer reviewed | - |
| dc.format | 22195 bytes | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | Nature Publishing Group | - |
| dc.relation | http://dx.doi.org/10.1038/nrg2268 | - |
| dc.rights | closedAccess | - |
| dc.subject | Genomic instability | - |
| dc.subject | Mutations | - |
| dc.subject | Mechanics | - |
| dc.title | Genome instability: a mechanistic view of its causes and consequences | - |
| dc.type | Artículo | - |
| Appears in Collections: | Digital Csic | |
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