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http://dspace.mediu.edu.my:8181/xmlui/handle/10261/4097| Title: | SMC proteins, new players in the maintenance of genomic stability |
| Keywords: | Sister chromatid exchange Double-strand break repair Homologous Recombination Break-induced replication Collapsed replication forks Cohesins MRX/MRN complex Smc5-Smc6 SMC complexes |
| Publisher: | Landes Bioscience |
| Description: | PMID: 17404505.-- Previously published online as a Cell Cycle E-publication:
http://www.landesbioscience.com/journals/cc/abstract.php?id=4107 Homologous recombination (HR) is one of the key mechanisms responsible for the repair of DNA double-strand breaks (DSBs), including those that occur during DNA replication. Recent studies in yeast and mammals have uncovered that the SMC complexes cohesins and Smc5-Smc6 are recruited to induced DSBs, and play a role in the maintenance of genome stability by favouring SCR as the main recombinational DSB repair mechanism. These new results raise intriguing questions such as whether SMC proteins might play a functional role at collapsed replication forks, which may represent the main source of spontaneous recombinogenic damage. A deeper knowledge of the role of SMC proteins in DSB repair should contribute to a better understanding of chromosome dynamics and stability. Peer reviewed |
| URI: | http://dspace.mediu.edu.my:8181/xmlui/handle/10261/4097 |
| Other Identifiers: | Cell Cycle 6(8): 914-918 (2007) 1538-4101 (Print) 1551-4005 (Online) http://hdl.handle.net/10261/4097 10.4161/cc.6.8.4107 |
| Appears in Collections: | Digital Csic |
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