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http://dspace.mediu.edu.my:8181/xmlui/handle/10261/4685| Title: | The Ultrabithorax Hox gene of Drosophila controls haltere size by regulating the Dpp pathway |
| Authors: | Ministerio de Economía y Competitividad (España) Comunidad de Madrid Fundación Ramón Areces Ministerio de Educación y Ciencia (España) European Commission Consejo Superior de Investigaciones Científicas (España) |
| Keywords: | Hox Ultrabithorax Decapentaplegic Size control Imaginal disc Drosophila |
| Publisher: | Company of Biologists |
| Description: | Article available at http://dx.doi.org/10.1242/dev.02609 The halteres and wings of Drosophila are homologous thoracic appendages, which share common positional information provided by signaling pathways. The activity in the haltere discs of the Ultrabithorax (Ubx) Hox gene establishes the differences between these structures, their different size being an obvious one. We show here that Ubx regulates the activity of the Decapentaplegic (Dpp) signaling pathway at different levels, and that this regulation is instrumental in establishing the size difference. Ubx downregulates dpp transcription and reduces Dpp diffusion by repressing the expression of master of thick veins and division abnormally delayed and by increasing the levels of thick veins, one of the Dpp receptors. Our results suggest that modulation in Dpp expression and spread accounts, in part, for the different size of halteres and wings. This work was supported by grants from the Dirección General de Investigación Científica y Técnica (N° BMC 2002-00300), the Comunidad Autónoma de Madrid (N° GR/SAL/0147/2004) and an Institutional Grant from the Fundación Ramón Areces. L.d.N. is supported by a fellowship from the Spanish Ministerio de Educación y Ciencia and D.L.G. by a I3P fellowship, co-financed by the European Social Fund, from the C.S.I.C. Peer reviewed |
| URI: | http://dspace.mediu.edu.my:8181/xmlui/handle/10261/4685 |
| Other Identifiers: | Development 133, 4495-4506 (2006) 0950-1991 http://hdl.handle.net/10261/4685 |
| Appears in Collections: | Digital Csic |
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