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Please use this identifier to cite or link to this item: http://dspace.mediu.edu.my:8181/xmlui/handle/10261/4693
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dc.contributorMinisterio de Educación y Ciencia (España)-
dc.contributorComunidad de Madrid-
dc.contributorFundación Ramón Areces-
dc.creatorNavas, Luis de-
dc.creatorForonda, David-
dc.creatorSuzanne, Magali-
dc.creatorSánchez-Herrero, Ernesto-
dc.date2008-05-30T11:58:45Z-
dc.date2008-05-30T11:58:45Z-
dc.date2006-08-02-
dc.date.accessioned2017-01-31T01:31:15Z-
dc.date.available2017-01-31T01:31:15Z-
dc.identifierMechanisms of Development, Volume 123, Issue 11, November 2006, Pages 860-867-
dc.identifier1872-6356 (Online)-
dc.identifier0925-4773 (Print)-
dc.identifierhttp://hdl.handle.net/10261/4693-
dc.identifier10.1016/j.mod.2006.07.010-
dc.identifier.urihttp://dspace.mediu.edu.my:8181/xmlui/handle/10261/4693-
dc.descriptionThe functional replacement of one gene product by another one is a powerful method to study specificity in development and evolution. In Drosophila, the Gal4/UAS method has been used to analyze in vivo such functional substitutions. To this aim, Gal4 lines that inactivate a gene and reproduce its expression pattern are required, and they can be frequently obtained by replacing pre-existing P-lacZ lines with such characteristics. We have devised a new method to quickly identify replacements of P-lacZ lines by P-Gal4 lines, and applied it successfully to obtain Gal4 insertions in the Ultrabithorax and Abdominal-B Hox genes. We have used these lines to study the functional replacement of a Hox gene by another one. Our experiments confirm that the abdominal-A gene can replace Ultrabithorax in haltere development but that it cannot substitute for Abdominal-B in the formation of the genitalia.-
dc.descriptionThis work was supported by grants from the Ministerio de Educación y Ciencia (BMC2002-00300), the Comunidad Autónoma de Madrid (No. 08.1/0031/2001.1 and GR/SAL/0147/2004) and an Institutional Grant from the Fundación Ramón Areces.-
dc.descriptionPeer reviewed-
dc.format1868034 bytes-
dc.format958179 bytes-
dc.format148169 bytes-
dc.format283789 bytes-
dc.format1644438 bytes-
dc.format408652 bytes-
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dc.languageeng-
dc.publisherElsevier-
dc.relationhttp://dx.doi.org/10.1016/j.mod.2006.07.010-
dc.rightsopenAccess-
dc.subjectDrosophila-
dc.subjectP-element-
dc.subjectBithorax complex-
dc.subjectGal4 lines-
dc.subjectUbx-
dc.subjectAbd-B-
dc.titleA simple and efficient method to identify replacements of P-lacZ by P-Gal4 lines allows obtaining Gal4 insertions in the bithorax complex of Drosophila-
dc.typeArtículo-
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