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Please use this identifier to cite or link to this item: http://dspace.mediu.edu.my:8181/xmlui/handle/10261/4699
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dc.contributorMinisterio de Economía y Competitividad (España)-
dc.contributorComunidad de Madrid-
dc.contributorFundación Ramón Areces-
dc.contributorMinisterio de Educación y Ciencia (España)-
dc.creatorManjón, Cristina-
dc.creatorSánchez-Herrero, Ernesto-
dc.creatorSuzanne, Magali-
dc.date2008-05-30T12:41:27Z-
dc.date2008-05-30T12:41:27Z-
dc.date2006-12-03-
dc.date.accessioned2017-01-31T01:31:25Z-
dc.date.available2017-01-31T01:31:25Z-
dc.identifierNature Cell Biology 9, 57 - 63 (2006)-
dc.identifier1465-7392 (Print)-
dc.identifier1476-4679 (Online)-
dc.identifierhttp://hdl.handle.net/10261/4699-
dc.identifier.urihttp://dspace.mediu.edu.my:8181/xmlui/handle/10261/4699-
dc.descriptionArticle available at http://dx.doi.org/10.1038/ncb1518-
dc.descriptionMorphogens are secreted signalling molecules that govern many developmental processes1. In the Drosophila wing disc, the transforming growth factor (TGF) homologue Decapentaplegic (Dpp) forms a smooth gradient and specifies cell fate by conferring a defined value of morphogen activity. Thus, neighbouring cells have similar amounts of Dpp protein, and if a sharp discontinuity in Dpp activity is generated between these cells, Jun kinase (JNK)-dependent apoptosis is triggered to restore graded positional information2, 3. To date, it has been assumed that this apoptotic process is only activated when normal signalling is distorted. However, we now show that a similar process occurs during normal development: rupture in Dpp activity occurs during normal segmentation of the distal legs of Drosophila. This sharp boundary of Dpp signalling, independently of the absolute level of Dpp activity, induces a JNK—reaper-dependent apoptosis required for the morphogenesis of a particular structure of the leg, the joint. Our results show that Dpp could induce a developmental programme not only in a concentration dependent manner, but also by the creation of a sharp boundary of Dpp activity. Furthermore, the same process could be used either to restore a normal pattern in response to artificial disturbance or to direct a morphogenetic process.-
dc.descriptionThis work has been supported by grants from the Dirección General de Investigación Científica y Técnica (BMC 2002-00300), the Comunidad Autónoma de Madrid (08.1/0031/2001.1 and GR/SAL/0147/2004) and an Institutional Grant from the Fundación Ramón Areces. C.M. is a recipient of a Formación del Personal Universitario (F.P.U.) fellowship from the Ministerio de Educación y Ciencia.-
dc.descriptionPeer reviewed-
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dc.format375162 bytes-
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dc.languageeng-
dc.publisherNature Publishing Group-
dc.rightsopenAccess-
dc.subjectDrosophila-
dc.subjectDecapentaplegic-
dc.titleSharp boundaries of Dpp signalling trigger local cell death required for Drosophila leg morphogenesis-
dc.typeArtículo-
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