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http://dspace.mediu.edu.my:8181/xmlui/handle/10261/4802| Title: | A conserved mechanism of Hedgehog gradient formation by lipid modifications |
| Authors: | Ministerio de Economía y Competitividad (España) Fundación Ramón Areces National Institutes of Health (US) March of Dimes Foundation |
| Keywords: | Drosophila Hedgehog |
| Publisher: | Elsevier |
| Description: | Members of the Hedgehog (Hh) family of proteins are conserved morphogens that modulate cell fates in target tissues in different developmental systems. Dysregulation of Hh signaling results in a wide range of human diseases. The mature Hh is modified by lipids in two places, with palmitate at the N-terminus and cholesterol at the C-terminus. The lipid modifications are essential to the proper secretion and spreading of the morphogen throughout the extracellular matrix, interacting with heparan sulfate proteoglycans. However, the role of lipid modifications in regulating the range and activity of Hh proteins remains controversial. Here, we aim to resolve this issue by providing a model that is consistent with current and past reports. We propose that the cholesterol moiety functions to restrict the dilution and deregulated spread of the morphogen in the extracellular space We also thank the support of the Spanish D.G.I.C.Y.T, grant BFU2005-04183 (I.G.), the Fundación Areces for an institutional grant (I.G.), National Institutes of Health grant HD049667 (C.C.) and March of Dimes foundation (C.C) Peer reviewed |
| URI: | http://dspace.mediu.edu.my:8181/xmlui/handle/10261/4802 |
| Other Identifiers: | Trends in Cell Biology Vol.17, Issue 1, January 2007, Pages 1-5 0962-8924 (Print) http://hdl.handle.net/10261/4802 10.1016/j.tcb.2006.11.002 |
| Appears in Collections: | Digital Csic |
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