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http://dspace.mediu.edu.my:8181/xmlui/handle/10261/5126| Title: | GTP-binding proteins of the Rho/Rac family: regulation, effectors and functions in vivo |
| Publisher: | Wiley-VCH |
| Description: | 24 páginas, 5 figuras, 1 tabla.-- El pdf del artículo es el manuscrito de autor. Rho/Rac proteins constitute a subgroup of the Ras superfamily of GTP hydrolases. Although originally implicated in the control of cytoskeletal events, it is currently known that these GTPases coordinate diverse cellular functions, including cell polarity, vesicular trafficking, the cell cycle and transcriptomal dynamics. In this review, we will provide an overview on the recent advances in this field regarding the mechanism of regulation and signaling, and the roles in vivo of this important GTPase family. Funding agencies: XRB’s work is supported by grants from the US National Cancer Institute (5R01-CA73735-10), the Spanish Ministry of Education and Science (SAF2003-00028), the Castilla-León Autonomous Government (SA053A05), and the Red Temática de Investigación Cooperativa en Cáncer (RD06/0020/0001, Spanish Ministry of Health). VS was supported by an EMBO long term postdoctoral fellowship. IMB was partially supported by a Spanish Ministry of Education and Science FPU fellowship (FP2000-6489). The Centro de Investigación del Cáncer is supported by endowments from the CSIC, University of Salamanca, Castilla-León Autonomous Government, the Red Temática de Investigacián Cooperativa de Centros de Cáncer (C03/10, Spanish Ministry of Health), and the Foundation for Cancer Research of Salamanca. Peer reviewed |
| URI: | http://dspace.mediu.edu.my:8181/xmlui/handle/10261/5126 |
| Other Identifiers: | BioEssays 29(4): 356–370 (2007) 0265-9247 PMC1971132 http://hdl.handle.net/10261/5126 10.1002/bies.20558 |
| Appears in Collections: | Digital Csic |
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