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| DC Field | Value | Language |
|---|---|---|
| dc.creator | Olmeda, David | - |
| dc.creator | Castel, Susanna | - |
| dc.creator | Vilaró, Senén | - |
| dc.creator | Cano, Amparo | - |
| dc.date | 2008-06-26T07:53:53Z | - |
| dc.date | 2008-06-26T07:53:53Z | - |
| dc.date | 2003-07 | - |
| dc.date.accessioned | 2017-01-31T01:54:47Z | - |
| dc.date.available | 2017-01-31T01:54:47Z | - |
| dc.identifier | Molecular Biology of the Cell 14(7): 2844–2860 (2003) | - |
| dc.identifier | 1059-1524 | - |
| dc.identifier | http://hdl.handle.net/10261/5356 | - |
| dc.identifier | 10.1091/mbc.E03-01-0865 | - |
| dc.identifier.uri | http://dspace.mediu.edu.my:8181/xmlui/handle/10261/5356 | - |
| dc.description | Copyright © by American Society for Cell Biology.-- Final full-text version of the paper available at: http://www.molbiolcell.org/content/vol14/issue7/ .-- Supplementary material available at: http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=165681&blobname=mbc_14_7_2844__.html | - |
| dc.description | β-catenin is a multifunctional protein involved in cell-cell adhesion and Wnt signal transduction. β-Catenin signaling has been proposed to act as inducer of cell proliferation in different tumors. However, in some developmental contexts and cell systems β-catenin also acts as a positive modulator of apoptosis. To get additional insights into the role of β-Catenin in the regulation of the cell cycle and apoptosis, we have analyzed the levels and subcellular localization of endogenous β-catenin and its relation with adenomatous polyposis coli (APC) during the cell cycle in S-phase–synchronized epithelial cells. β-Catenin levels increase in S phase, reaching maximum accumulation at late G2/M and then abruptly decreasing as the cells enter into a new G1 phase. In parallel, an increased cytoplasmic and nuclear localization of β-catenin and APC is observed during S and G2 phases. In addition, strong colocalization of APC with centrosomes, but not β-catenin, is detected in M phase. Interestingly, overexpression of a stable form of β-catenin, or inhibition of endogenous β-catenin degradation, in epidermal keratinocyte cells induces a G2 cell cycle arrest and leads to apoptosis. These results support a role for β-catenin in the control of cell cycle and apoptosis at G2/M in normal and transformed epidermal keratinocytes. | - |
| dc.description | This work was supported by grants from the Comisión Interministerial de Ciencia y Tecnología (SAF98–0085-C03–01 and SAF2001–2819), Instituto de Salud Carlos III (FIS01/1174) and Comunidad Autónoma de Madrid (08.1/0055/2000) to AC. During the realization of this work D.O. was a predoctoral fellow of the Spanish Ministry of Science and Technology. | - |
| dc.description | Peer reviewed | - |
| dc.format | 1254187 bytes | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | American Society for Cell Biology | - |
| dc.relation | http://dx.doi.org/10.1091/mbc.E03-01-0865 | - |
| dc.rights | openAccess | - |
| dc.title | β-Catenin regulation during the cell cycle: Implications in G2/M and apoptosis | - |
| dc.type | Artículo | - |
| Appears in Collections: | Digital Csic | |
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