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http://dspace.mediu.edu.my:8181/xmlui/handle/123456789/4044| Title: | Induction of cholesterol efflux in the CNS |
| Keywords: | apolipoprotein apoE ABC-A1 LXR oxysterols Alzheimer's disease cholesterol homeostasis efflux neurodegeneration lipoprotein apolipoprotein LRP Down' syndrome ApoE4 HMGCoA reductase lipids LDLr LRP receptor injury Niemann Pick C (NPC) |
| Issue Date: | 30-May-2013 |
| Publisher: | Neurobiology of Lipids |
| Description: | Intricate cellular mechanisms exist for maintaining proper cholesterol levels. Several recent studies of removal of excess cholesterol in the CNS have focused on the ABC-A1 lipid transporter and its regulation via the LXR nuclear hormone receptor. Cellular cholesterol is hydroxylated to form oxysterols (24-hydroxycholesterol in the brain), which bind LXR and promote gene transcription. LXR activation increases levels of ABC-A1 and apoE, which together act to remove cholesterol and other lipids from cells. Recent studies including Liang et al. suggest manipulation of the LXR system alters brain cholesterol homeostasis and apoE levels, and thus could be beneficial in approaches to Alzheimer disease therapeutics. |
| URI: | http://koha.mediu.edu.my:8181/jspui/handle/123456789/4044 |
| Other Identifiers: | http://neurobiologyoflipids.org/content/3/1/ http://www.doaj.org/doaj?func=openurl&genre=article&issn=16835506&date=2004&volume=3&issue=&spage=1 |
| Appears in Collections: | Biology and Life Sciences |
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