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http://dspace.mediu.edu.my:8181/xmlui/handle/123456789/4392| Title: | Prevention of reperfusion lung injury by lidocaine in isolated rat lung ventilated with higher oxygen levels. |
| Keywords: | Animal Comparative Study Lidocaine pharmacology Lung drug effects Male Models Animal Oxygen administration & dosage Rats Rats Sprague-Dawley Reperfusion Injury prevention & control Support U.S. Gov′t P.H.S. |
| Issue Date: | 30-May-2013 |
| Publisher: | Medknow Publications |
| Description: | BACKGROUND: Lidocaine, an antiarrhythmic drug has been shown to be effective against post-ischaemic reperfusion injury in heart. However, its effect on pulmonary reperfusion injury has not been investigated. AIMS: We investigated the effects of lidocaine on a postischaemic reperfused rat lung model. MATERIALS AND METHODS: Lungs were isolated and perfused at constant flow with Krebs-Henseilet buffer containing 4% bovine serum albumin, and ventilated with 95% oxygen mixed with 5% CO2. Lungs were subjected to ischaemia by stopping perfusion for 60 minutes followed by reperfusion for 10 minutes. Ischaemia was induced in normothermic conditions. RESULTS: Postischaemic reperfusion caused significant (p < 0.0001) higher wet-to-dry lung weight ratio, pulmonary arterial pressure and peak airway pressure compared to control lungs. Lidocaine, at a dose of 5mg/Kg b.w. was found to significantly (p < 0.0001) attenuate the increase in the wet-to-dry lung weight ratio, pulmonary arterial pressure and peak airway pressure observed in post-ischaemic lungs. CONCLUSION: Lidocaine is effective in preventing post-ischaemic reperfusion injury in isolated, perfused rat lung. |
| URI: | http://koha.mediu.edu.my:8181/jspui/handle/123456789/4392 |
| Other Identifiers: | http://www.jpgmonline.com/article.asp?issn=0022-3859;year=2003;volume=49;issue=1;spage=17;epage=20;aulast=Das http://www.doaj.org/doaj?func=openurl&genre=article&issn=00223859&date=2003&volume=49&issue=1&spage=17 |
| Appears in Collections: | Health Sciences |
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