1. DSpace at MEDIU
  2. مقالات مستوردة من دليل الدوريات مفتوحة المصدر DOAJ
  3. Health Sciences
Please use this identifier to cite or link to this item: http://dspace.mediu.edu.my:8181/xmlui/handle/123456789/4392
Full metadata record
DC FieldValueLanguage
dc.creatorDas K-
dc.creatorMisra H-
dc.date2003-
dc.date.accessioned2013-05-30T11:09:12Z-
dc.date.available2013-05-30T11:09:12Z-
dc.date.issued2013-05-30-
dc.identifierhttp://www.jpgmonline.com/article.asp?issn=0022-3859;year=2003;volume=49;issue=1;spage=17;epage=20;aulast=Das-
dc.identifierhttp://www.doaj.org/doaj?func=openurl&genre=article&issn=00223859&date=2003&volume=49&issue=1&spage=17-
dc.identifier.urihttp://koha.mediu.edu.my:8181/jspui/handle/123456789/4392-
dc.descriptionBACKGROUND: Lidocaine, an antiarrhythmic drug has been shown to be effective against post-ischaemic reperfusion injury in heart. However, its effect on pulmonary reperfusion injury has not been investigated. AIMS: We investigated the effects of lidocaine on a postischaemic reperfused rat lung model. MATERIALS AND METHODS: Lungs were isolated and perfused at constant flow with Krebs-Henseilet buffer containing 4% bovine serum albumin, and ventilated with 95% oxygen mixed with 5% CO2. Lungs were subjected to ischaemia by stopping perfusion for 60 minutes followed by reperfusion for 10 minutes. Ischaemia was induced in normothermic conditions. RESULTS: Postischaemic reperfusion caused significant (p < 0.0001) higher wet-to-dry lung weight ratio, pulmonary arterial pressure and peak airway pressure compared to control lungs. Lidocaine, at a dose of 5mg/Kg b.w. was found to significantly (p < 0.0001) attenuate the increase in the wet-to-dry lung weight ratio, pulmonary arterial pressure and peak airway pressure observed in post-ischaemic lungs. CONCLUSION: Lidocaine is effective in preventing post-ischaemic reperfusion injury in isolated, perfused rat lung.-
dc.publisherMedknow Publications-
dc.sourceJournal of Postgraduate Medicine-
dc.subjectAnimal-
dc.subjectComparative Study-
dc.subjectLidocaine-
dc.subjectpharmacology-
dc.subjectLung-
dc.subjectdrug effects-
dc.subjectMale-
dc.subjectModels-
dc.subjectAnimal-
dc.subjectOxygen-
dc.subjectadministration & dosage-
dc.subjectRats-
dc.subjectRats-
dc.subjectSprague-Dawley-
dc.subjectReperfusion Injury-
dc.subjectprevention & control-
dc.subjectSupport-
dc.subjectU.S. Gov′t-
dc.subjectP.H.S.-
dc.titlePrevention of reperfusion lung injury by lidocaine in isolated rat lung ventilated with higher oxygen levels.-
Appears in Collections:Health Sciences

Files in This Item:
There are no files associated with this item.
Show simple item record


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.