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http://dspace.mediu.edu.my:8181/xmlui/handle/123456789/4404| Title: | Malignant tumours of the minor salivary glands: a survival analysis of 17 years from a tertiary referral cancer centre. |
| Keywords: | Adolescent Adult Aged Carcinoma diagnosis pathology therapy Disease-Free Survival Female Human Male Middle Age Neoplasm Staging Palate pathology Retrospective Studies Salivary Gland Neoplasms diagnosis pathology therapy Survival Analysis Treatment Outcome |
| Issue Date: | 30-May-2013 |
| Publisher: | Medknow Publications |
| Description: | BACKGROUND: Malignant tumours of the minor salivary glands are rare and constitute less than 0.5% of all malignant neoplasms. AIM: This study was carried out to evaluate the clinical presentation, site distribution, treatment, survival and predictors of survival in malignant minor salivary gland tumours. SETTING: A tertiary care, superspeciality referral hospital. DESIGN: Retrospective analysis. PATIENTS AND METHOD: Forty-two cases of minor salivary gland tumours treated over a period of 17 years were reviewed for clinical presentation, histopathology, stage distribution, treatment and treatment outcome. STATISTICAL ANALYSIS: Survival by Kaplan Meier Method and the outcomes were compared using log-rank test. RESULTS: The mean age of the patients was 46.9 years with a male to female ratio of 1.4:1. Majority of the patients presented with a painless progressive swelling, with 13 (31%) of them in T2 stage. About one-third of the patients had palpable lymph nodes at presentation, while none had distant metastasis. Palate was the commonest site and mucoepidermoid carcinoma was the commonest hispathological type. About 1/3 of the patients were treated with primary surgery and were followed up by adjuvant radiotherapy. Seven patients underwent palliative treatment alone. Over a mean follow-up of 30 months, 5 patients failed. The disease free survival was 72% at 5-year, none of the factors studied were found to significantly influence survival. CONCLUSIONS: Results of the present study suggest that minor salivary gland tumours should be treated with primary surgery irrespective of site and histological type to achieve best loco-regional control and survival. |
| URI: | http://koha.mediu.edu.my:8181/jspui/handle/123456789/4404 |
| Other Identifiers: | http://www.jpgmonline.com/article.asp?issn=0022-3859;year=2003;volume=49;issue=1;spage=25;epage=8;aulast=Pandey http://www.doaj.org/doaj?func=openurl&genre=article&issn=00223859&date=2003&volume=49&issue=1&spage=25 |
| Appears in Collections: | Health Sciences |
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