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http://dspace.mediu.edu.my:8181/xmlui/handle/123456789/4824Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.creator | M. Dolores Blanco | - |
| dc.creator | Sandra Guerrero | - |
| dc.creator | Marta Benito | - |
| dc.creator | Ana Fernández | - |
| dc.creator | César Teijón | - |
| dc.creator | Rosa Olmo | - |
| dc.creator | Issa Katime | - |
| dc.creator | José M. Teijón | - |
| dc.date | 2011 | - |
| dc.date.accessioned | 2013-05-30T11:48:09Z | - |
| dc.date.available | 2013-05-30T11:48:09Z | - |
| dc.date.issued | 2013-05-30 | - |
| dc.identifier | http://www.mdpi.com/2073-4360/3/3/1107/ | - |
| dc.identifier | http://www.doaj.org/doaj?func=openurl&genre=article&issn=20734360&date=2011&volume=3&issue=3&spage=1107 | - |
| dc.identifier.uri | http://koha.mediu.edu.my:8181/jspui/handle/123456789/4824 | - |
| dc.description | Folate-targeted poly[(p-nitrophenyl acrylate)-co-(N-isopropylacrylamide)] nanohydrogel (F-SubMG) was loaded with 5-fluorouracil (5-FU) to obtain low (16.3 ± 1.9 μg 5-FU/mg F-SubMG) and high (46.8 ± 3.8 μg 5-FU/mg F-SubMG) load 5-FU-loaded F-SubMGs. The complete in vitro drug release took place in 8 h. The cytotoxicity of unloaded F-SubMGs in MCF7 and HeLa cells was low; although it increased for high F-SubMG concentration. The administration of 10 μM 5-FU by 5-FU-loaded F-SubMGs was effective on both cellular types. Cell uptake of F-SubMGs took place in both cell types, but it was higher in HeLa cells because they are folate receptor positive. After subcutaneous administration (28 mg 5-FU/kg b.w.) in Wistar rats, F-SubMGs were detected at the site of injection under the skin. Histological studies indicated that the F-SubMGs were surrounded by connective tissue, without any signs of rejections, even 60 days after injection. Pharmacokinetic study showed an increase in MRT (mean residence time) of 5-FU when the drug was administered by drug-loaded F-SubMGs. | - |
| dc.language | eng | - |
| dc.publisher | Molecular Diversity Preservation International | - |
| dc.source | Polymers | - |
| dc.subject | drug delivery | - |
| dc.subject | folate-conjugate nanogel | - |
| dc.subject | 5-fluorouracil | - |
| dc.subject | culture cells | - |
| dc.subject | pharmacokinetic | - |
| dc.title | In Vitro and In Vivo Evaluation of a Folate-Targeted Copolymeric Submicrohydrogel Based on N-Isopropylacrylamide as 5-Fluorouracil Delivery System | - |
| Appears in Collections: | Science General | |
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