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Please use this identifier to cite or link to this item: http://dspace.mediu.edu.my:8181/xmlui/handle/123456789/5627
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dc.creatorRim Chatter-
dc.creatorRym Ben Othman-
dc.creatorSameh Rabhi-
dc.creatorMaria Kladi-
dc.creatorSafa Tarhouni-
dc.creatorConstantinos Vagias-
dc.creatorVassilios Roussis-
dc.creatorLamia Guizani-Tabbane-
dc.creatorRiadh Kharrat-
dc.date2011-
dc.date.accessioned2013-05-30T13:09:09Z-
dc.date.available2013-05-30T13:09:09Z-
dc.date.issued2013-05-30-
dc.identifierhttp://www.mdpi.com/1660-3397/9/7/1293/-
dc.identifierhttp://www.doaj.org/doaj?func=openurl&genre=article&issn=16603397&date=2011&volume=9&issue=7&spage=1293-
dc.identifier.urihttp://koha.mediu.edu.my:8181/jspui/handle/123456789/5627-
dc.descriptionNeorogioltriol is a tricyclic brominated diterpenoid isolated from the organic extract of the red algae Laurencia glandulifera. In the present study, the anti-inflammatory effects of neorogioltriol were evaluated both in vivo using carrageenan-induced paw edema and in vitro on lipopolysaccharide (LPS)-treated Raw264.7 macrophages. The in vivo study demonstrated that the administration of 1 mg/kg of neorogioltriol resulted in the significant reduction of carregeenan-induced rat edema. In vitro, our results show that neorogioltriol treatment decreased the luciferase activity in LPS-stimulated Raw264.7 cells, stably transfected with the NF-κB-dependent luciferase reporter. This effect on NF-κB activation is not mediated through MAPK pathways. The inhibition of NF-κB activity correlates with decreased levels of LPS-induced tumor necrosis factor-alpha (TNFα) present in neorogioltriol treated supernatant cell culture. Further analyses indicated that this product also significantly inhibited the release of nitric oxide and the expression of cyclooxygenase-2 (COX-2) in LPS-stimulated Raw264.7 cells. These latter effects could only be observed for neorogioltriol concentrations below 62.5 µM. To our knowledge, this is the first report describing a molecule derived from Laurencia glandulifera with anti-inflammatory activity both in vivo and in vitro. The effect demonstrated in vitro may be explained by the inhibition of the LPS-induced NF-κB activation and TNFα production. NO release and COX-2 expression may reinforce this effect.-
dc.languageeng-
dc.publisherMolecular Diversity Preservation International-
dc.sourceMarine Drugs-
dc.subjectanti-inflammatory-
dc.subjectneorogioltriol-
dc.subjectLaurencia-
dc.subjectTNFα-
dc.subjectNF-κB-
dc.subjectNO-
dc.subjectCOX-2-
dc.subjectcarrageenan-
dc.titleIn Vivo and in Vitro Anti-Inflammatory Activity of Neorogioltriol, a New Diterpene Extracted from the Red Algae Laurencia glandulifera-
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