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http://dspace.mediu.edu.my:8181/xmlui/handle/123456789/5637| Title: | Evolution of Tumor Metabolism might Reflect Carcinogenesis as a Reverse Evolution process (Dismantling of Multicellularity) |
| Keywords: | Warburg-effect Crabtree-effect Pasteur-effect lactate symbiosis cannibalism reverse evolution convergent evolution |
| Issue Date: | 30-May-2013 |
| Publisher: | Molecular Diversity Preservation International |
| Description: | Carcinogenesis occurs through a series of steps from normal into benign and finally malignant phenotype. This cancer evolutionary trajectory has been accompanied by similar metabolic transformation from normal metabolism into Pasteur and/or Crabtree-Effects into Warburg-Effect and finally Cannibalism and/or Lactate-Symbiosis. Due to lactate production as an end-product of glycolysis, tumor colonies acquire new phenotypes that rely on lactate as energetic fuel. Presence of Warburg-Effect indicates that some tumor cells undergo partial (if not complete) de-endosymbiosis and so cancer cells have been become unicellular microorganism (anti-Dollo’s Law) specially when they evolve to develop cannibalism as way of metabolism while oxidative types of cells that rely on lactate, as their energetic fuel, might represent extra-endosymbiosis. Thus, at the end, the cancer colony could be considered as integrated metabolic ecosystem. Proper understanding of tumor metabolism will contribute to discover potential anticancer agents besides conventional chemotherapy. |
| URI: | http://koha.mediu.edu.my:8181/jspui/handle/123456789/5637 |
| Other Identifiers: | http://www.mdpi.com/2072-6694/3/3/3002/ http://www.doaj.org/doaj?func=openurl&genre=article&issn=20726694&date=2011&volume=3&issue=3&spage=3002 |
| Appears in Collections: | Health Sciences |
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