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http://dspace.mediu.edu.my:8181/xmlui/handle/123456789/5637Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.creator | Khalid O. Alfarouk | - |
| dc.creator | Mohammed E.A. Shayoub | - |
| dc.creator | Abdel Khalig Muddathir | - |
| dc.creator | Gamal O. Elhassan | - |
| dc.creator | Adil H.H. Bashir | - |
| dc.date | 2011 | - |
| dc.date.accessioned | 2013-05-30T13:10:12Z | - |
| dc.date.available | 2013-05-30T13:10:12Z | - |
| dc.date.issued | 2013-05-30 | - |
| dc.identifier | http://www.mdpi.com/2072-6694/3/3/3002/ | - |
| dc.identifier | http://www.doaj.org/doaj?func=openurl&genre=article&issn=20726694&date=2011&volume=3&issue=3&spage=3002 | - |
| dc.identifier.uri | http://koha.mediu.edu.my:8181/jspui/handle/123456789/5637 | - |
| dc.description | Carcinogenesis occurs through a series of steps from normal into benign and finally malignant phenotype. This cancer evolutionary trajectory has been accompanied by similar metabolic transformation from normal metabolism into Pasteur and/or Crabtree-Effects into Warburg-Effect and finally Cannibalism and/or Lactate-Symbiosis. Due to lactate production as an end-product of glycolysis, tumor colonies acquire new phenotypes that rely on lactate as energetic fuel. Presence of Warburg-Effect indicates that some tumor cells undergo partial (if not complete) de-endosymbiosis and so cancer cells have been become unicellular microorganism (anti-Dollo’s Law) specially when they evolve to develop cannibalism as way of metabolism while oxidative types of cells that rely on lactate, as their energetic fuel, might represent extra-endosymbiosis. Thus, at the end, the cancer colony could be considered as integrated metabolic ecosystem. Proper understanding of tumor metabolism will contribute to discover potential anticancer agents besides conventional chemotherapy. | - |
| dc.language | eng | - |
| dc.publisher | Molecular Diversity Preservation International | - |
| dc.source | Cancers | - |
| dc.subject | Warburg-effect | - |
| dc.subject | Crabtree-effect | - |
| dc.subject | Pasteur-effect | - |
| dc.subject | lactate symbiosis | - |
| dc.subject | cannibalism | - |
| dc.subject | reverse evolution | - |
| dc.subject | convergent evolution | - |
| dc.title | Evolution of Tumor Metabolism might Reflect Carcinogenesis as a Reverse Evolution process (Dismantling of Multicellularity) | - |
| Appears in Collections: | Health Sciences | |
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