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http://dspace.mediu.edu.my:8181/xmlui/handle/123456789/5701| Title: | Application to Dissolution Assessments; A Facile and Rapid procedure of Atenolol and Hydrochlorothiazide in Pharmaceutical Formulation by RP-HPLC assay Method |
| Keywords: | Atenolol Hydrochlorothiazide RP-HPLC Analytical method validation |
| Issue Date: | 30-May-2013 |
| Publisher: | Association of Pharmaceutical Innovators |
| Description: | A RP-HPLC method was developed and validated for quantitative determination of Atenolol and Hydrochlorothiazide in pharmaceutical dosage forms. The chromatography was carried out on a 25 cm × 4.6 mm i.d, 5-μm particle, Phenomenex Luna C18 column under reversed-phase partition chromatographic conditions. The mobile phase was a mixture of ammonium acetate (0.02M, pH 4.0 adjusted with glacial acetic acid) and acetonitrile in ratio of 40:60 (v/v) at a flow rate of 1.0ml/min. Clarithromycin was used as an internal standard. The linearity was established in the range of 20 - 400 ng/ml Atenolol and 5-150 ng/ml Hydrochlorothiazide for HPLC. This validated method can be used for estimation of Atenolol and Hydrochlorothiazide in pharmaceutical suspension. |
| URI: | http://koha.mediu.edu.my:8181/jspui/handle/123456789/5701 |
| Other Identifiers: | http://ditonline.info/article/view/8119/4145 http://www.doaj.org/doaj?func=openurl&genre=article&issn=09757619&date=2011&volume=3&issue=6&spage=100 |
| Appears in Collections: | Health Sciences |
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