Analysis of a Proposed First Generation Physical Map of the Human Genome

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DC Field	Value	Language
dc.creator	Kaufman, Alan	-
dc.creator	Orlin, James B., 1953-	-
dc.date	2004-05-28T19:33:52Z	-
dc.date	2004-05-28T19:33:52Z	-
dc.date	1994-08	-
dc.date.accessioned	2013-10-09T02:39:04Z	-
dc.date.available	2013-10-09T02:39:04Z	-
dc.date.issued	2013-10-09	-
dc.identifier	http://hdl.handle.net/1721.1/5326	-
dc.identifier.uri	http://koha.mediu.edu.my:8181/xmlui/handle/1721	-
dc.description	Cohen and colleagues [1] recently described a project to characterize a human yeast artificial chromosome (YAC) library and offered a 'proposed data analysis strategy' that was said to yield a physical map covering 87% of the human genome. The authors provided no analytical evaluation to test the validity of their novel strategy for constructing 'paths' in the genome. We have now examined the proposed method in detail. Analytical studies show that most paths with at most two YACs or spanning less than 5 cM are valid, but most paths involving four or more YACs or spanning 5 cM or more are invalid. After restricting the map to paths with a high probability of being valid, we conclude that the remaining map properly covers at most 36% of the genome.	-
dc.format	463844 bytes	-
dc.format	application/pdf	-
dc.language	en_US	-
dc.publisher	Massachusetts Institute of Technology, Operations Research Center	-
dc.relation	Operations Research Center Working Paper;OR 295-94	-
dc.title	Analysis of a Proposed First Generation Physical Map of the Human Genome	-
dc.type	Working Paper	-
Appears in Collections:	MIT Items

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