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http://dspace.mediu.edu.my:8181/xmlui/handle/1721.1/6410Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.creator | Koch, Christof | - |
| dc.date | 2004-10-04T14:55:31Z | - |
| dc.date | 2004-10-04T14:55:31Z | - |
| dc.date | 1984-03-01 | - |
| dc.date.accessioned | 2013-10-09T02:45:19Z | - |
| dc.date.available | 2013-10-09T02:45:19Z | - |
| dc.date.issued | 2013-10-09 | - |
| dc.identifier | AIM-787 | - |
| dc.identifier | http://hdl.handle.net/1721.1/6410 | - |
| dc.identifier.uri | http://koha.mediu.edu.my:8181/xmlui/handle/1721 | - |
| dc.description | Electron microscope studies of relay cells in the lateral geniculate nucleus of the CAT have shown that the retinal input of X-cells is associated with a special synaptic circuitry, termed the spine-triad complex. The retinal afferents make an asymmetrical synapse with both a dendritic appendage of the X-cell and a geniculate interneuron. The interneuron contacts in turn the same dendritic appendage with a symmetrical synaptic profile. The retinal input to geniculate Y-cells is predominately found on dendritic shafts without any triadic arrangement. We explore the integrative properties of X- and Y-cells resulting from this striking dichotomy in synaptic architecture. The basis of our analysis is the solution of the cable equation for a branched dendritic tree with a known somatic input resistance. Under the assumption that the geniculate interneuron mediates a shunting inhibition, activation of the interneuron reduces very efficiently the excitatory post-synaptic potential induced by the retinal afferent without affecting the electrical activity in the rest of the cell. Therefore, the spine-triad circuit implements the analogy of an AND-NOT gate, unique to the X-system. Functionally, this corresponds to a presynaptic, feed-forward type of inhibition of the optic tract terminal. Since Y-cells lack this structure, inhibition acts globally, reducing the general electrical activity of the cell. We propose that geniculate interneurons gate the flow of visual information into the X-system as a function of the behavioral state of the animal, enhancing the center-surround antagonism and possibly mediating reciprocal lateral inhibition, eye-movement related suppression and selective visual attention. | - |
| dc.format | 8025534 bytes | - |
| dc.format | 6306024 bytes | - |
| dc.format | application/postscript | - |
| dc.format | application/pdf | - |
| dc.language | en_US | - |
| dc.relation | AIM-787 | - |
| dc.title | A Theoretical Analysis of the Electrical Properties of a X-Cell in the Cat's LGN | - |
| Appears in Collections: | MIT Items | |
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