Health Sciences

Effectiveness of maintenance treatments for nonsmall cell lung cancer

2013-05-30T00:00:00Z

Effectiveness of maintenance treatments for nonsmall cell lung cancer Matthew J Eadens, Steven I Robinson, Katharine AR PriceDivision of Medical Oncology, Mayo Clinic, Rochester, MN, USAAbstract: Maintenance therapy for advanced nonsmall cell lung cancer has shown some clinical benefit for patients by improving progression-free survival and, to a lesser extent, overall survival. Two main strategies exist for maintenance therapy, ie, continuation and switch maintenance. Continuation maintenance involves the continued use of one of the induction drugs beyond 4–6 cycles of initial treatment. Switch maintenance utilizes a third agent initiated after first-line chemotherapy. Both cytotoxic agents and targeted agents have been studied. Switch maintenance therapy with pemetrexed in nonsquamous tumors and erlotinib appear to show the most clear clinical benefit. Continuation maintenance with bevacizumab has shown improvement in progression-free survival. Data concerning the role of cetuximab for maintenance is conflicting. Toxicity, quality of life, and cost are important confounding issues that need to be considered. Several ongoing Phase III trials are investigating strategies to improve on the current agents as well as testing promising new therapies.Keywords: lung cancer, chemotherapy, maintenance therapy, targeted therapy

THE EFFECT OF ENDURANCE TRAINING ON REGULAR TREATMENT PROCEDURE AND ULTRA-RAPID OPIUM THERAPY (UROT) OF ADDICTED VOLUNTEERS IN SELECTED TREATMENT CENTERS OF TEHRAN

2013-05-30T00:00:00Z

THE EFFECT OF ENDURANCE TRAINING ON REGULAR TREATMENT PROCEDURE AND ULTRA-RAPID OPIUM THERAPY (UROT) OF ADDICTED VOLUNTEERS IN SELECTED TREATMENT CENTERS OF TEHRAN The purpose of this study was to assess the effect of regular endurance training on treatmentprocedure of addicted males. The subjects in this experiment were volunteers for treatment inselected opium therapy centers of Tehran. The highly motivated participants for treatmentselected as statistical population. 288 addicted people [ 22 – 24 years old, weight 62+ 3.5 kg,height 169.3 + 2.7 cm, addiction duration 2 + 0.3 years and Vo2 max 38+ 6.3(ml/kg/min)] whomtreated with methadone, and different usual treatment procedures like Ultra Rapid OpiumTherapy (UROT), day treatment, treatment at home and acrostic methods were selected. For thisreason, RTCQ (readiness to change questionnaire), ASUP (addiction substances using pattern)questionnaires were used. Urine analysis was used to detect treatment period and recovery andlapse indicators. Bruce test and clinical survey were used for eight control and experimentalgroups. After treatment procedure, regular exercises were started in experimental groups.Schedule of exercise was 3days per week continues aerobic training during 8 weeks and itstraining patterns for participants were assessed and devised by trained physicians. Recovery andlapse during treatment period was detected by urine analysis. Findings suggests lapse in addictedpeoples who used regular trainings were less than the others. This findings show that regulartraining has bilateral effect on VO2max and better treatments in experimental groups.

EFFECT OF COMBINATION EXERCISE TRAINING ON SEX HORMONE BINDING GLOBULIN IN POSTMENOPAUSAL WOMEN WITH BREAST CANCER

2013-05-30T00:00:00Z

EFFECT OF COMBINATION EXERCISE TRAINING ON SEX HORMONE BINDING GLOBULIN IN POSTMENOPAUSAL WOMEN WITH BREAST CANCER Studies indicated that decreased sex hormone binding globulin (SHBG) can increase the risk ofbreast cancer and its recurrences in postmenopausal women. On the other hand; it’s possible thatexercise training can affect SHBG. Therefore; the aim of current study was to clarify the effectof combination exercise training on SHBG in postmenopausal women with breast cancer. Thus;29 postmenopausal women with breast cancer that received surgery; chemotherapy and radiationtherapy divided in to two groups; experimental and control. Subjects of experimental groupperformed 15 weeks combination exercise training including walking (2 sessions per week) andresistance training (2 sessions per week different from walking days). Pre and post of 15 weeks;body weight; BMI andserum SHBG levels were measured in to two groups. Data were analyzedusing by ANCOVA and significant levels set as p<0.05. The findings of present studydemonstrated that combination exercise training has significant effect on body weight; BMI andserum SHBG levels (p< 0.05). In experimental group; body weight and BMI were decreased andSHBG levels were increased; after 15 weeks. In conclusion; combination exercise training canincrease serum SHBG levels in postmenopausal women with breast cancer; significantly.Because of elevated serum or plasma SHBG levels can reduce risk of breast cancer and itsrecurrences; combination exercise training during treatment can reduce recurrence of breastcancer by increased levels of SHBG.

EFFECT OF GLUCOSE FEEDING RESPONSES ON PLASMA GHRELIN AND GH AFTER A SINGLE SESSION OF AEROBIC EXERCISE IN MALE

2013-05-30T00:00:00Z

EFFECT OF GLUCOSE FEEDING RESPONSES ON PLASMA GHRELIN AND GH AFTER A SINGLE SESSION OF AEROBIC EXERCISE IN MALE The aim of this study was investigation of the effect of glucose on plasma ghrelin; GH; andglucose after a single session of aerobic exercise in young man.Material and Method: Twelve Unathletic student men separated randomly in two groups (glucoseand water). Consecutive-one mail running was performed; with 3 min resting in the end of eachmail. Blood samples were taken at before; immediately and 90min after exercise. Plasma ghrelin;GH and glucose were measured. Possible statistically significant differences were determined bytwo-factor ANOVA for repeated were employed. The difference detected by ANOVA werelocated with a LSD (with Benferoni correction) post hoc test.Results: showed that ghrelin and GH significantly increased immediately after exercise.Discussion: Data indicate that a higher ghrelin in the present study might be attributed a liverglycogen and ATP deficiency and an incomplete energy source recovery after exercise.