المستودع الأكاديمي جامعة المدينة

Role of the PI3K regulatory subunit in the control of actin organization and cell migration

أعرض تسجيلة المادة بشكل مبسط

dc.creator Jiménez, Concepción
dc.creator Armas Portela, Rosario
dc.creator Mellado, Mario
dc.creator Rodríguez Frade, José M.
dc.creator Collard, John
dc.creator Serrano, Antonio
dc.creator Martínez-Alonso, Carlos
dc.creator Ávila, Jesús
dc.creator Carrera, Ana C.
dc.date 2008-03-31T09:59:06Z
dc.date 2008-03-31T09:59:06Z
dc.date 2000-10
dc.date.accessioned 2017-01-31T01:01:21Z
dc.date.available 2017-01-31T01:01:21Z
dc.identifier The Journal of Cell Biology, volume 151, number 2, october 16, 2000, pp. 249–261
dc.identifier 0021-9525
dc.identifier http://hdl.handle.net/10261/3386
dc.identifier.uri http://dspace.mediu.edu.my:8181/xmlui/handle/10261/3386
dc.description Copyright © by The Rockefeller University Press
dc.description Cell migration represents an important cellular response that utilizes cytoskeletal reorganization as its driving force. Here, we describe a new signaling cascade linking PDGF receptor stimulation to actin rearrangements and cell migration. We demonstrate that PDGF activates Cdc42 and its downstream effector N-WASP to mediate filopodia formation, actin stress fiber disassembly, and a reduction in focal adhesion complexes. Induction of the Cdc42 pathway is independent of phosphoinositide 3-kinase (PI3K) enzymatic activity, but it is dependent on the p85 a regulatory subunit of PI3K. Finally, data are provided showing that activation of this pathway is required for PDGF-induced cell migration on collagen. These observations show the essential role of the PI3K regulatory subunit p85 a in controlling PDGF receptor–induced cytoskeletal changes and cell migration, illustrating a novel signaling pathway that links receptor stimulation at the cell membrane with actin dynamics
dc.description Peer reviewed
dc.format 804197 bytes
dc.format application/pdf
dc.language eng
dc.publisher Rockefeller University Press
dc.rights openAccess
dc.subject N-WASP
dc.subject Cdc42
dc.subject PDGF
dc.subject Phosphatidylinositol 3-kinase
dc.subject Actin cytoskeleton
dc.title Role of the PI3K regulatory subunit in the control of actin organization and cell migration
dc.type Artículo


الملفات في هذه المادة

الملفات الحجم الصيغة عرض

لا توجد أي ملفات مرتبطة بهذه المادة.

هذه المادة تبدو في المجموعات التالية:

أعرض تسجيلة المادة بشكل مبسط