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Early effects of iodine deficiency on radial glial cells of the hippocampus of the rat fetus. A model of neurological cretinism

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dc.creator Martínez-Galán, Juan Ramón
dc.creator Pedraza, Pablo
dc.creator Santacana, María
dc.creator Escobar del Rey, Francisco
dc.creator Morreale de Escobar, Gabriella
dc.creator Ruiz-Marcos, Antonio
dc.date 2008-06-24T08:39:14Z
dc.date 2008-06-24T08:39:14Z
dc.date 1997-06-01
dc.date.accessioned 2017-01-31T01:46:19Z
dc.date.available 2017-01-31T01:46:19Z
dc.identifier Journal of Clinical Investigation 99(11): 2701-2709 (1997)
dc.identifier 0021-9738
dc.identifier http://hdl.handle.net/10261/5250
dc.identifier 10.1172/JCI119459
dc.identifier.uri http://dspace.mediu.edu.my:8181/xmlui/handle/10261/5250
dc.description PMCID: PMC508116
dc.description The most severe brain damage associated with thyroid dysfunction during development is observed in neurological cretins from areas with marked iodine deficiency. The damage is irreversible by birth and related to maternal hypothyroxinemia before mid gestation. However, direct evidence of this etiopathogenic mechanism is lacking. Rats were fed diets with a very low iodine content (LID), or LID supplemented with KI. Other rats were fed the breeding diet with a normal iodine content plus a goitrogen, methimazole (MMI). The concentrations of -thyroxine (T4) and 3,5,3'triiodo--thyronine (T3) were determined in the brain of 21-d-old fetuses. The proportion of radial glial cell fibers expressing nestin and glial fibrillary acidic protein was determined in the CA1 region of the hippocampus. T4 and T3 were decreased in the brain of the LID and MMI fetuses, as compared to their respective controls. The number of immature glial cell fibers, expressing nestin, was not affected, but the proportion of mature glial cell fibers, expressing glial fibrillary acidic protein, was significantly decreased by both LID and MMI treatment of the dams. These results show impaired maturation of cells involved in neuronal migration in the hippocampus, a region known to be affected in cretinism, at a stage of development equivalent to mid gestation in humans. The impairment is related to fetal cerebral thyroid hormone deficiency during a period of development when maternal thyroxinemia is believed to play an important role.
dc.description This investigation has been supported by grants to Dr. A. Ruiz-Marcos from the “Fondo para Investigaciones Sanitarias de la Seguridad Social” (grant 93/0160) and from the “Comisión Interministerial de Ciencia y Tecnología” (grant PM95-0011) and a grant to Dr. G. Morreale de Escobar from “Fondo para Investigaciones Sanitarias de la Seguridad Social” (grant 92/0888).
dc.description Peer reviewed
dc.format 658560 bytes
dc.format application/pdf
dc.language eng
dc.publisher American Society for Clinical Investigation
dc.relation http://dx.doi.org/10.1172/JCI119459
dc.rights openAccess
dc.subject Brain
dc.subject Thyroxine
dc.subject Triiodothyronine
dc.subject Glial-fibrillary-acidic-protein
dc.subject Nestin
dc.title Early effects of iodine deficiency on radial glial cells of the hippocampus of the rat fetus. A model of neurological cretinism
dc.type Artículo


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