| dc.creator |
Franck Dufour |
|
| dc.creator |
Wei-Qin Zhao |
|
| dc.creator |
Lakshmi Ravindranath |
|
| dc.creator |
Daniel L. Alkon |
|
| dc.date |
2003 |
|
| dc.date.accessioned |
2013-05-30T10:16:28Z |
|
| dc.date.available |
2013-05-30T10:16:28Z |
|
| dc.date.issued |
2013-05-30 |
|
| dc.identifier |
http://neurobiologyoflipids.org/content/1/7/ |
|
| dc.identifier |
http://www.doaj.org/doaj?func=openurl&genre=article&issn=16835506&date=2003&volume=1&issue=&spage=34 |
|
| dc.identifier.uri |
http://koha.mediu.edu.my:8181/jspui/handle/123456789/4050 |
|
| dc.description |
Cholesterol has recently received attention as a potentially important factor in Alzheimer's disease (AD) etiology. Caveolin, which binds cholesterol, plays a prominent role in cellular cholesterol transport. Here, we found a higher level of cholesterol and caveolin in the caveolae-enriched fractions prepared from AD patients' fibroblasts compared with age and sex matched controls (AC). Furthermore, the cross-linking activation of the prion protein, which is known to link to signal transduction of caveolin, is altered in AD fibroblasts. Our results suggest a dysregulation of cholesterol processing in AD fibroblasts which may contribute to the pathogenesis of AD. |
|
| dc.publisher |
Neurobiology of Lipids |
|
| dc.source |
Neurobiology of Lipids |
|
| dc.subject |
Alzheimer's disease |
|
| dc.subject |
amyloid beta precursor |
|
| dc.subject |
APP |
|
| dc.subject |
Down syndrome |
|
| dc.subject |
etiology |
|
| dc.subject |
lipids |
|
| dc.subject |
lipoprotein |
|
| dc.subject |
neurodegeneration marker |
|
| dc.subject |
secretase |
|
| dc.subject |
caveolin |
|
| dc.subject |
caveolae |
|
| dc.subject |
membrane |
|
| dc.subject |
cell culture |
|
| dc.subject |
human |
|
| dc.subject |
non-neuronal tissue |
|
| dc.subject |
neurodegenerative disease |
|
| dc.subject |
signal transduction |
|
| dc.subject |
prion |
|
| dc.subject |
PKC |
|
| dc.subject |
cross-linking |
|
| dc.subject |
fractioning |
|
| dc.subject |
biochemistry |
|
| dc.subject |
triton |
|
| dc.title |
Abnormal cholesterol processing in Alzheimer's disease patient's fibroblasts |
|