المستودع الأكاديمي جامعة المدينة

Abnormal cholesterol processing in Alzheimer's disease patient's fibroblasts

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dc.creator Franck Dufour
dc.creator Wei-Qin Zhao
dc.creator Lakshmi Ravindranath
dc.creator Daniel L. Alkon
dc.date 2003
dc.date.accessioned 2013-05-30T10:16:28Z
dc.date.available 2013-05-30T10:16:28Z
dc.date.issued 2013-05-30
dc.identifier http://neurobiologyoflipids.org/content/1/7/
dc.identifier http://www.doaj.org/doaj?func=openurl&genre=article&issn=16835506&date=2003&volume=1&issue=&spage=34
dc.identifier.uri http://koha.mediu.edu.my:8181/jspui/handle/123456789/4050
dc.description Cholesterol has recently received attention as a potentially important factor in Alzheimer's disease (AD) etiology. Caveolin, which binds cholesterol, plays a prominent role in cellular cholesterol transport. Here, we found a higher level of cholesterol and caveolin in the caveolae-enriched fractions prepared from AD patients' fibroblasts compared with age and sex matched controls (AC). Furthermore, the cross-linking activation of the prion protein, which is known to link to signal transduction of caveolin, is altered in AD fibroblasts. Our results suggest a dysregulation of cholesterol processing in AD fibroblasts which may contribute to the pathogenesis of AD.
dc.publisher Neurobiology of Lipids
dc.source Neurobiology of Lipids
dc.subject Alzheimer's disease
dc.subject amyloid beta precursor
dc.subject APP
dc.subject Down syndrome
dc.subject etiology
dc.subject lipids
dc.subject lipoprotein
dc.subject neurodegeneration marker
dc.subject secretase
dc.subject caveolin
dc.subject caveolae
dc.subject membrane
dc.subject cell culture
dc.subject human
dc.subject non-neuronal tissue
dc.subject neurodegenerative disease
dc.subject signal transduction
dc.subject prion
dc.subject PKC
dc.subject cross-linking
dc.subject fractioning
dc.subject biochemistry
dc.subject triton
dc.title Abnormal cholesterol processing in Alzheimer's disease patient's fibroblasts


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