| dc.creator |
Seong, Jiehyun |
|
| dc.creator |
Lee, Seok-Won |
|
| dc.creator |
Jun, Shinae |
|
| dc.creator |
Choi, Hyun-Goo |
|
| dc.creator |
Laibinis, Paul E. |
|
| dc.date |
2003-12-08T16:02:44Z |
|
| dc.date |
2003-12-08T16:02:44Z |
|
| dc.date |
2003-01 |
|
| dc.date.accessioned |
2013-10-09T02:32:30Z |
|
| dc.date.available |
2013-10-09T02:32:30Z |
|
| dc.date.issued |
2013-10-09 |
|
| dc.identifier |
http://hdl.handle.net/1721.1/3791 |
|
| dc.identifier.uri |
http://koha.mediu.edu.my:8181/xmlui/handle/1721 |
|
| dc.description |
We have investigated a series of molecular and polymeric approaches for generating adherent thin films that impart anti-fouling characteristics to oxide surfaces. These films incorporate oligo- or poly(ethylene glycol) moieties that are expressed in high density in the near-surface region. In our molecular approach, oligo(ethylene glycol)-terminated n-alkyl-trichlorosilanes, RO(CH₂CH₂O)₃(CH₂)₁₁SiCl₃, have been designed so to spontaneously adsorb onto oxide surfaces and produce densely packed films. Another strategy uses a surface initiated polymerization to generate reactive anchored polymer chains that are then chemically modified to incorporate oligo(ethylene glycol) units. Lastly, a comb copolymer comprising a poly(acrylic acid) backbone and different grafting ratios of a linear poly(ethylene oxide-r-propylene oxide) chain has been prepared that adsorbs onto surfaces and forms a poly(ethylene glycol)-exposing film in single step. These surface coatings provide varying levels of protein and cellular resistance that can be related to molecular-scale elements of their surface structure. |
|
| dc.description |
Singapore-MIT Alliance (SMA) |
|
| dc.format |
444006 bytes |
|
| dc.format |
application/pdf |
|
| dc.language |
en_US |
|
| dc.relation |
Molecular Engineering of Biological and Chemical Systems (MEBCS); |
|
| dc.subject |
polymer coatings |
|
| dc.subject |
protein adsorption |
|
| dc.subject |
surface modification |
|
| dc.subject |
thin films |
|
| dc.title |
Self-Assembled Coatings for Controlling Biomolecular Adsorption on Surfaces |
|
| dc.type |
Article |
|