| dc.creator |
Chow, Gan-Moog |
|
| dc.date |
2003-12-16T14:00:17Z |
|
| dc.date |
2003-12-16T14:00:17Z |
|
| dc.date |
2004-01 |
|
| dc.date.accessioned |
2013-10-09T02:33:15Z |
|
| dc.date.available |
2013-10-09T02:33:15Z |
|
| dc.date.issued |
2013-10-09 |
|
| dc.identifier |
http://hdl.handle.net/1721.1/3936 |
|
| dc.identifier.uri |
http://koha.mediu.edu.my:8181/xmlui/handle/1721 |
|
| dc.description |
Nanoparticles were synthesized and modified for target drug delivery. The research involved the aqueous synthesis of near infrared (NIR) sensitive Au-Au<sub>2</sub>S nanoparticles. An anti-cancer drug (<i>cis-platin</i>) was subsequently adsorbed onto the Au-Au<sub>2</sub>S nanoparticle surface via the 11-mercaptoundecanoic acid layers. The results showed that the degree of adsorption of cis-platin onto Au-Au<sub>2</sub>S nanoparticles was controlled by the pH value of solution, and the rate of drug release was sensitive to NIR irradiation. The results of the synthesis, drug-release properties and nanoparticle-cell interactions will be discussed. |
|
| dc.description |
Singapore-MIT Alliance (SMA) |
|
| dc.format |
12186 bytes |
|
| dc.format |
application/pdf |
|
| dc.language |
en_US |
|
| dc.relation |
Molecular Engineering of Biological and Chemical Systems (MEBCS); |
|
| dc.subject |
nanoparticles |
|
| dc.subject |
targeted drug delivery |
|
| dc.subject |
near infrared sensitive Au-Au<sub>2</sub>S nanoparticles |
|
| dc.subject |
anti-cancer drugs |
|
| dc.subject |
NIR irradiation |
|
| dc.subject |
adsorption of cis-platin |
|
| dc.title |
Nanoparticles for Targeted Drug Delivery |
|
| dc.type |
Article |
|