| dc.creator |
Tam, Michael K. C. |
|
| dc.date |
2003-12-16T14:29:04Z |
|
| dc.date |
2003-12-16T14:29:04Z |
|
| dc.date |
2004-01 |
|
| dc.date.accessioned |
2013-10-09T02:33:18Z |
|
| dc.date.available |
2013-10-09T02:33:18Z |
|
| dc.date.issued |
2013-10-09 |
|
| dc.identifier |
http://hdl.handle.net/1721.1/3951 |
|
| dc.identifier.uri |
http://koha.mediu.edu.my:8181/xmlui/handle/1721 |
|
| dc.description |
This talk will focus on the development of polymeric nano-structured systems for drug and gene delivery applications. Two major classes of polymer systems will be considered; namely poly(ethylene-oxide-b-propylene-oxide-b-ethylene-oxide) (Pluronics) tri-block copolymers (FDA approved) and methacrylic acid (MAA) block and random copolymers. These polymers were functionalised with biodegradable or stimuli-sensitive functional groups to produce stimuli-sensitive nano-structure for efficient delivery of drugs and DNAs.
The atom transfer radical polymerisation (ATRP) was adopted to synthesize a range of mono-dispersed block copolymers (e.g. PEO-b-MAA, MMA-b-MAA). Ring opening polymerization method was used to functionalize Pulronics with degradable functional groups, such as lactide (LA), and caprolactone (CL). Other stimuli-sensitive functional groups such as methacrylic acid was used to impart pH sensitivity to the polymers. Various types of methacrylic acid block and random cross-linked copolymers and other novel systems, such as fullerene based block copolymers were synthesized. Detailed mechanism and physics that control the micellization, microstructure and drug/polymer interactions will be discussed. |
|
| dc.description |
Singapore-MIT Alliance (SMA) |
|
| dc.format |
12331 bytes |
|
| dc.format |
application/pdf |
|
| dc.language |
en_US |
|
| dc.relation |
Molecular Engineering of Biological and Chemical Systems (MEBCS); |
|
| dc.subject |
drug and gene delivery applications |
|
| dc.subject |
stimuli responsive polymers |
|
| dc.title |
Stimuli Responsive Polymers for Enhanced Drug Release Applications |
|
| dc.type |
Article |
|