| dc.creator |
Deshmukh, Smeet |
|
| dc.creator |
Bromberg, Lev |
|
| dc.creator |
Hatton, T. Alan |
|
| dc.date |
2003-12-16T14:30:52Z |
|
| dc.date |
2003-12-16T14:30:52Z |
|
| dc.date |
2004-01 |
|
| dc.date.accessioned |
2013-10-09T02:33:18Z |
|
| dc.date.available |
2013-10-09T02:33:18Z |
|
| dc.date.issued |
2013-10-09 |
|
| dc.identifier |
http://hdl.handle.net/1721.1/3952 |
|
| dc.identifier.uri |
http://koha.mediu.edu.my:8181/xmlui/handle/1721 |
|
| dc.description |
Facile, one-step synthesis of self-assembling, cationic block copolymers of poly(2-N-(dimethylaminoethyl) methacrylate) (pDMAEMA) and PEO-PPO-PEO (Pluronic®) is developed. The copolymers are obtained via free-radical polymerization of DMAEMA initiated by Pluronic-radicals generated by cerium (IV). The copolymers possess surface activity, are polycationic at pH<7.1, and self-assemble into micelle-like aggregates when neutralized. Potential applications of the novel copolymers for DNA transfection in gene therapy are discussed. |
|
| dc.description |
Singapore-MIT Alliance (SMA) |
|
| dc.format |
335893 bytes |
|
| dc.format |
application/pdf |
|
| dc.language |
en_US |
|
| dc.relation |
Molecular Engineering of Biological and Chemical Systems (MEBCS); |
|
| dc.subject |
poly(2-N-(dimethylaminoethyl) methacrylate) Pluronic® |
|
| dc.subject |
cerium (IV) |
|
| dc.subject |
free-radical polymerization |
|
| dc.subject |
self-assembly |
|
| dc.subject |
gene therapy |
|
| dc.title |
Synthesis and Properties of Novel Cationic, Temperature-Sensitive Block-Copolymers |
|
| dc.type |
Article |
|