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Trans-membrane Signal Transduction and Biochemical Turing Pattern Formation

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dc.creator Millonas, Mark M.
dc.creator Rauch, Erik M.
dc.date 2004-10-04T14:15:16Z
dc.date 2004-10-04T14:15:16Z
dc.date 1999-09-28
dc.date.accessioned 2013-10-09T02:42:00Z
dc.date.available 2013-10-09T02:42:00Z
dc.date.issued 2013-10-09
dc.identifier AIM-1670
dc.identifier http://hdl.handle.net/1721.1/5925
dc.identifier.uri http://koha.mediu.edu.my:8181/xmlui/handle/1721
dc.description The Turing mechanism for the production of a broken spatial symmetry in an initially homogeneous system of reacting and diffusing substances has attracted much interest as a potential model for certain aspects of morphogenesis such as pre-patterning in the embryo, and has also served as a model for self-organization in more generic systems. The two features necessary for the formation of Turing patterns are short-range autocatalysis and long-range inhibition which usually only occur when the diffusion rate of the inhibitor is significantly greater than that of the activator. This observation has sometimes been used to cast doubt on applicability of the Turing mechanism to cellular patterning since many messenger molecules that diffuse between cells do so at more-or-less similar rates. Here we show that stationary, symmetry-breaking Turing patterns can form in physiologically realistic systems even when the extracellular diffusion coefficients are equal; the kinetic properties of the 'receiver' and 'transmitter' proteins responsible for signal transduction will be primary factors governing this process.
dc.format 14 p.
dc.format 1482843 bytes
dc.format 525229 bytes
dc.format application/postscript
dc.format application/pdf
dc.language en_US
dc.relation AIM-1670
dc.subject AI
dc.subject MIT
dc.subject Artificial Intelligence
dc.subject pattern formation
dc.subject morphogenesis
dc.subject Turing patterns
dc.title Trans-membrane Signal Transduction and Biochemical Turing Pattern Formation


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