This thesis explores ways to augment a model-based diagnostic program with a learning component, so that it speeds up as it solves problems. Several learning components are proposed, each exploiting a different kind of similarity between diagnostic examples. Through analysis and experiments, we explore the effect each learning component has on the performance of a model-based diagnostic program. We also analyze more abstractly the performance effects of Explanation-Based Generalization, a technology that is used in several of the proposed learning components.